Background: The Nurses' Health Study II (NHS-II), which enrolled over 116,000 female nurses, provides a unique opportunity to investigate whether migraine is associated with MS and to explore the temporal aspects of the interrelationship.
Objectives: To calculate risk of MS among NHS-II participants with and without migraine.
Results: The prevalence of migraine in women with MS at baseline (26%, p = 0.11) and those diagnosed with MS after enrolment (29%, p < 0.0001) was higher than in the non-MS cases (21%).
The risk of developing MS in woman with migraine was 1.39 times higher than in non-migraine sufferers.