Sunday, 14 October 2012

ECTRIMS 2012: shedding some light on vitamin D and MS


9 comments:

  1. The Australian neurologist at about 3 mins into this says they did a small trial with only 23 MS patients and those taking 1000 IUs did better than those taking 6000 IUs- less relapses and sustained disability. He does say it was too small a study and they need to do a bigger one. I presume you're still suggesting that we should take 5000 IUs daily?

    ReplyDelete
  2. What the Australian neurologist said worried me too

    ReplyDelete
  3. He said "I don't want to say that taking high dose is bad"....but I agree surely this is how it sounded

    A study of n=23 is probably going to too small to show anything biological. This may suggest that less than 12 people were in a group (I have not seen the data), by chance you get some relapses in one group.It could give one result.

    There must be thousands of MSers out there using 5,000 units a day and if it were causing relapse more alarm bells would be ringing. When you have a group meeting ask how much vitamin D you are taking and who has been relapsing you will get idea if there are more than 12 of you then if right loads should have had problems. We have to wait for the proper study to occur, but
    other studies using larger n would not support this.

    http://www.ncbi.nlm.nih.gov/pubmed/22783368bad science

    ReplyDelete
  4. This trial with vitamin D2 has been critisized in Neurology, but I don't have access to Neurology. Who has...

    Neurology. 2012 Mar 13;78(11):841.
    A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis.
    Grimaldi L, Barkhof F, Beelke M, Burton J, Holmoy T, Hupperts R, Killestein J, Rieckmann P, Schluep M, Smolders J; SOLAR Study Group.
    Collaborators (53)
    Comment on
    A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis. [Neurology. 2011] PMID: 22411961

    ReplyDelete
  5. I have prog MS and take 10,000 IU of vitamin D3 every day. Dr. Ram of Barts has advocated 10,000 IU as what MSers need as they are likely to have weaker bones than the normal populace.

    Vit D3 has not improved my MS progression but when I consider that so many cells in the human body require vit D the it makes sense to have it in substantial doses. Because I don't have relapses it's hard for me to pass comment, though I have never read any evidence that having up to 75,000 IU of vit D3 has caused anybody any issues.

    It's probably a heck of a lot more safer than most DMTs on the market.

    ReplyDelete
    Replies
    1. "I have never read any evidence that having up to 75,000 IU of vit D3 has caused anybody any issues"

      Have you ever read any evidence that having up to 75,000 IU of vit D3 does not cause issues?

      I'll let Prof G comment on this, but this is significantly above recommended limits. If you eat enough toothpaste it is dangerous.

      Delete
    2. MouseDoctor, Prof G himself once gave a report on a lead MS researcher who recomends 10,000 IU vD3 per-day for MSers. 10,000 IU x7days= 70,000 IU per week.

      In that sense I can claim that upto 75,000 IU per week of vit D3 ought to be safe. The Vitamin D Council advocates 10,000 IU of vitamin D3 everyday.

      After 3 months of such high doses I feel fine, all things considered.My PPMS is no better, but hey, surely I'm doing the right thing by ingesting vit D3 capsules at 10,000 IU, aren't I?

      Delete
    3. You are trying to trick me, you never said 75,000 a week. The inference I got was a day so (525,000 a week)

      Delete
    4. Dude, I said 10,000 IU vit D3 "every day." Not trying to trick you.

      10 x 7 = 70. Now, I also take cod liver capsules and an A-Z multivitamin, which also contain vit D3. My cereal is also fortified with vitamin D. I, therefore, assume I am consuming up to 75,000 IU of vit D3 every week.

      I'll be hoest, even at 75,000 IU my PPMS feels no better, but I don't think it's supposed to. I suppose the real people who will benefit from vitamin D3 are kids under the age of 15 as, according to Dr. Alister Coles, MS is a disease that happens before the age of 15 but takes years to properly materialise.

      Delete

Please note that all comments are moderated and any personal or marketing-related submissions will not be shown.